E100
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E100
Fluka
(−)-Eseroline fumarate salt
solid
| CAS Number: | 104015-29-4 |
| Linear Formula: | C13H18N2O · C4H4O4 |
| Molecular Weight: | 334.37 |
| MDL number: | MFCD00055202 |
| PubChem Substance ID: | 24277834 |
Description
| Biochem/physiol Actions | Metabolite of physostigmine (eserine) that is cytotoxic in several neuronal cell lines; it displays both anti-acetylcholinesterase and opiate agonist activities; potent analgesic. |
| Caution | Hygroscopic, photosensitive |
Properties
| form | solid |
| optical activity | [α]23/D −107.9°, c = 0.5 in methanol(lit.) |
| color | white |
| solubility | 0.1 M HCl: Solutions should be freshly prepared.soluble |
| 0.1 M NaOH: Solutions should be freshly prepared.soluble | |
| H2O: Solutions should be freshly prepared.soluble | |
| methanol: Solutions should be freshly prepared. slightly soluble | |
| Gene Information | human ... ACHE(43) |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Galli, A., et al., In vitro and in vivo protection of acetylcholinesterase by eseroline against inactivation by diisopropyl fluorophosphate and carbamates. J. Pharm. Pharmacol. 37, 42, (1985) Abstract |
| Furst, S. et al., Direct evidence that eseroline possesses morphine-like effects. Eur. J. Pharmacol. 83, 232, (1982) | |
| Galli, A., et al., Reversible inhibition of acetylcholinesterase by eseroline, an opioid agonist structurally related to physostigmine (eserine) and morphine. Biochem. Pharmacol. 31, 1233, (1982) Abstract | |
| Somani, S.M., et al., Eseroline, a metabolite of physostigmine, induces neuronal cell death. Toxicol. Appl. Pharmacol. 106, 28, (1990) Abstract |
